Molecular Docking Study: Phyllanthus niruri L.'s Active Compounds as Dengue Haemorrhagic Fever Therapy

نویسندگان

چکیده

Dengue Haemorrhagic Fever is a disease caused by the dengue virus through mosquito vector Aedes aegypti. NS3 Helicase known as one of nonstructural proteins consisting some essential enzymes for replication. Nowadays ivermectin has been developed an anti-dengue haemorrhagic fever with therapy target Helicase. The therapeutics drug not found specifically. Methanol extract meniran (Phyllanthus niruri L.) reported activity to concentration 15,63 μg/mL. This research aimed study interactions and affinity active compound receptor (NS3 Helicase) know ADME toxicity profile. From 56 compounds meniran, there was best candidate which energy binding (ΔG) Inhibition Constanta (IC) lower than native ligand ivermectin, it nirurin -4.87 kcal/mol. These have good absorption distribution profiles so they are thought be candidates targeting better ligands.

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ژورنال

عنوان ژورنال: IJPST (Indonesian Journal Pharmaceutival Science and Technology)

سال: 2022

ISSN: ['2356-1971', '2406-856X']

DOI: https://doi.org/10.24198/ijpst.v1i1.42824